Tales of Mystery and Imagination often rendered as Tales of Mystery and Imagination is a popular title for posthumous compilations of writings by American author, essayist and poet Edgar Allan Poe and was the first complete collection of his works specifically restricting itself to his suspenseful and related tales.

In 1839, during Poe's lifetime, a collection of his strange tales was published, but it did not include some highly regarded tales which were written later, including "The Murders in the Rue Morgue" and "A Descent into the Maelström". The first posthumous collection of Poe's works was compiled in 1850 and included a memoir from Rufus Wilmot Griswold, but this did not confine itself to his tales of suspense and related tales. Several collections of Poe's prose and poetry followed. The precursor to Tales of Mystery and Imagination was a collection of Poe's works entitled Tales of Mystery, Imagination and Humor. The title "Tales of Mystery and Imagination" was first used by "The World's Classics", London, and printed by Grant Richard, 48 Leicester Sq. in 1902. The title of this collection was then adopted by Padraic Colum in 1908 in view of the growing reputation of Poe's taste for suspense, especially in the context of what his French critic M. Brunetiere called events "on the margin" of life. The original collection, in keeping with its title, deliberately excluded Poe's poems, comedies and essays. In his introduction to the 1908 edition Colum cites a reason for his adoption of this selection: his opinion that "tales" as opposed to "short stories" were so short that they tended to lack descriptions of socially important experiences. Colum hence also left out two works as too lengthy, these being The Narrative of Arthur Gordon Pym of Nantucket and "The Unparalleled Adventure of One Hans Pfaall".