American Crime Story is an American anthology true crime television series developed by Scott Alexander and Larry Karaszewski, who are also executive producers, alongside Brad Falchuk, Nina Jacobson, Ryan Murphy, and Brad Simpson. The series is the second installment in the American Story media franchise, following American Horror Story. Each season is presented as a self-contained miniseries and is independent of the events in other seasons. Alexander and Karaszewski did not return after the first season, but retain executive-producer credits. In the United States, the series is broadcast on FX.

The first season, subtitled The People v. O. J. Simpson, chronicled the murder trial of O. J. Simpson, and was based on the book The Run of His Life: The People v. O. J. Simpson by Jeffrey Toobin. It premiered on February 2, 2016.The second season, subtitled The Assassination of Gianni Versace, chronicled the murder of designer Gianni Versace by spree-killer Andrew Cunanan, and based on the book Vulgar Favors by Maureen Orth. It premiered on January 17, 2018, and concluded on March 21, 2018. The third season, subtitled Impeachment, chronicles the Clinton–Lewinsky scandal, and is based on the book A Vast Conspiracy: The Real Story of the Sex Scandal That Nearly Brought Down a President, also by Toobin. It premiered on September 7, 2021.

A season based on the aftermath of Hurricane Katrina, had been in development, but in February 2019 FX announced that the idea had been abandoned. A potential fourth season, tentatively titled Studio 54, which would focus on the rise and fall of Studio 54 owners Steve Rubell and Ian Schrager, is in development.